ea0012oc3 | Young Endocrinologist prize session | SFE2006
White NE
, Dhillo WS
, Small CJ
, Lui YL
, Gardiner JV
, Ghatei MA
, Bloom SR
BackgroundSR141716 (Rimonabant) has been shown to significantly inhibit food intake and reduce body weight in rodents and humans by antagonising CB1 receptors. The gut hormones peptide YY336 (PYY336) and oxyntomodulin (OXM), released from L-cells in the small intestine inhibit food intake in both rodents and humans and this effect is thought to be mediated via the hypothalamus.Objective<...